---
title: "Selank: what sources report"
url: https://humanpeptides.fyi/peptides/selank
site: humanpeptides.fyi
last_reviewed: 2026-10-11
---


# Selank

> humanpeptides.fyi makes no claims of its own. Every statement below reports what a cited source says, with its link. Not medical advice.

Selank: Synthetic heptapeptide analogue of the immune peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia as an intranasal anxiolytic/nootropic. The sources cited here most often discuss it for: Less anxiety, small open studies; Less fatigue, small studies; Immune modulation, small study. Evidence label: Early human.

## At a glance

- **Type:** Peptide
- **Family:** Mind & Mood
- **Evidence label:** Early human (3 of 5)
- **Regulatory status:** FDA lists selank acetate (TP-7) among compounding nominations withdrawn by their nominators after being placed in its safety-risk category, noting possible immunogenicity and that the agency lacks important information on its safety in humans.
- **Goals discussed:** Calm & Mood, Energy & Endurance, Focus & Cognition, Immunity
- **Also called:** TP-7, Selank acetate, Selanc, TKPRPGP, Thr-Lys-Pro-Arg-Pro-Gly-Pro, NA-Selank, N-Acetyl Selank Amidate, selank nasal spray, chill peptide
- **Last reviewed:** 2026-10-11

## What is Selank?

- Synthetic heptapeptide analogue of the immune peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia as an intranasal anxiolytic/nootropic; thought to allosterically modulate GABA-A signaling and enkephalin breakdown; registered drug in Russia, NOT FDA-approved. Sources: <https://pubmed.ncbi.nlm.nih.gov/18454096/>, <https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/>

NA-Selank (N-acetyl selank amidate) is a chemically modified analog sold in the research market; it is not the drug registered in Russia and has its own, thinner evidence base.

**Regulatory status:** FDA lists selank acetate (TP-7) among compounding nominations withdrawn by their nominators after being placed in its safety-risk category, noting possible immunogenicity and that the agency lacks important information on its safety in humans. Source: <https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks>

## What is Selank researched for?

### 1. Less anxiety, small open studies

- Reduces anxiety in generalized anxiety disorder/neurasthenia comparably to benzodiazepine medazepam (small Russian human comparative study, not placebo-controlled) Sources: <https://pubmed.ncbi.nlm.nih.gov/18454096/>, <https://europepmc.org/article/med/18454096>, <https://www.cambridge.org/core/journals/european-psychiatry/article/p1114-rapid-and-slow-response-during-treatment-of-generalized-anxiety-disorder-with-peptide-anxiolytic-selank/7A497218D37084BD079EFE143126F56E>
- Goals: [Calm & Mood](https://humanpeptides.fyi/objectives/mood)

### 2. Less fatigue, small studies

- Improved asthenia (fatigue) and cognition in anxious patients (human study) and enhanced learning/memory retention in rats (animal) Sources: <https://pubmed.ncbi.nlm.nih.gov/18454096/>, <https://pubmed.ncbi.nlm.nih.gov/20919548/>
- Goals: [Energy & Endurance](https://humanpeptides.fyi/objectives/energy), [Focus & Cognition](https://humanpeptides.fyi/objectives/mind)

### 3. Immune modulation, small study

- Immunomodulation: altered Th1/Th2 cytokine balance and IL-6 gene expression in patients with anxiety-asthenic disorders (small human study) Sources: <https://pubmed.ncbi.nlm.nih.gov/18577961/>, <https://titratelab.com/research/pubmed/24291245>
- Goals: [Immunity](https://humanpeptides.fyi/objectives/immunity)

## What do researchers and users say about Selank?

> "The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system."
>
> Volkova A, et al., Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission (Frontiers in Pharmacology, 2016). <https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/>

Context: Rat study measuring expression of 84 neurotransmission genes in the frontal cortex after Selank or GABA.

> "FDA lacks important information regarding any safety issues raised by selank acetate administered to humans."
>
> US Food and Drug Administration, Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks. <https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks>

Context: FDA safety summary for selank acetate (TP-7), listed among compounding nominations that were later withdrawn.

> "Tried it a couple years back for similar reasons, it smoothed out the sharp edges of anxiety without making me foggy. The effect was subtle but noticeable, like background noise turning down a notch."
>
> Anonymous user, r/Nootropics, How has your experience with Selank been?. <https://www.reddit.com/r/Nootropics/comments/1vwnxm1/how_has_your_experience_with_selank_been/>

Context: Forum reply about intranasal Selank for anxiety; several other replies in the same thread report no effect at all.

## What side effects of Selank are reported?

- Nasal irritation, sleep changes, occasional nausea/elevated heart rate, brief dulling (anecdotal Reddit) Sources: <https://www.reddit.com/r/NooTopics/comments/13lpbv7/does_anyone_has_experience_with_selank/>, <https://www.reddit.com/r/Nootropics/comments/1vwnxm1/how_has_your_experience_with_selank_been/>
- No long-term Western safety data Sources: <https://www.cambridge.org/core/journals/european-psychiatry/article/p1114-rapid-and-slow-response-during-treatment-of-generalized-anxiety-disorder-with-peptide-anxiolytic-selank/7A497218D37084BD079EFE143126F56E>
- FDA flags a possible immunogenicity risk from aggregation and peptide-related impurities in compounded selank acetate, and says it lacks human safety information. (FDA assessment) Sources: <https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks>
- Drowsiness reported by some intranasal users. (anecdotal) Sources: <https://www.reddit.com/r/Biohacking/comments/1vw4lg4/semax_selank_protocol_need_advice/>

## What do peptide guides say about Selank?

- **Dr. Axe:** Dr. Axe's library rates Selank research-only and not FDA-approved, and says its cited human study looked at anxiety symptoms only, establishing neither cognitive enhancement nor a mechanism in people. <https://draxe.com/peptide-calculator/selank/>
- **PepEdHub:** PepEdHub describes Selank as a tuftsin-derived peptide with an added Pro-Gly-Pro tail for stability, says Russia approved it as a prescription anxiolytic, and reports no dependence, tolerance or withdrawal effects. <https://pepedhub.com/peptides/selank/>
- **Seek Peptides:** Seek Peptides lists Selank for anxiety, focus and mood without sedation, while describing its effects as subtle. <https://www.seekpeptides.com/blog/articles/complete-peptide-list>
- **NCBI PMC:** In rats, Selank shifted expression of 45 neurotransmission genes within an hour, a pattern that tracked GABA's own effects and suggests GABA-system modulation; this is animal data, not a human trial. <https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/>

## What does the research say, system by system?

### Hormones & physiology

- Modulates inflammation-related gene expression and cytokines (IL-6, Th1/Th2) (human cells/animal) Sources: <https://pubmed.ncbi.nlm.nih.gov/18577961/>, <https://pillbuys.com/research/Selank/11.pdf>

### Brain, mood & sleep

- Alters expression of GABAergic neurotransmission genes, suggesting allosteric GABA-A modulation (animal/cell) Sources: <https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/>, <https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00089/full>
- Users report calmer mood, reduced social anxiety and better focus; some report no effect or paradoxical insomnia/anxiety (anecdotal Reddit) Sources: <https://www.reddit.com/r/PeptideNasalSpray/comments/1thzuir/selank_nasal_spray_5_day_report_great_for_anxiety/>, <https://www.reddit.com/r/Selank/comments/1ua8dqx/paradoxical_insomniaanxiety_reaction_to_selank/>

### Also notable

- Marketed as non-sedating, non-addictive alternative to benzodiazepines, though no Western placebo-controlled trials exist Sources: <https://pubmed.ncbi.nlm.nih.gov/18454096/>

## How strong is the evidence for Selank?

**Early human** (3 of 5). Small Russian human studies (not placebo-controlled) + animal data + anecdotes; approved in Russia only

_Small, short, old, unblinded or single-group human studies._

## Street names and stacks

- Street names: [The Chill Peptide](https://humanpeptides.fyi/street-names#nick-chill)

## Questions about Selank

### What is Selank?

Synthetic heptapeptide analogue of the immune peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia as an intranasal anxiolytic/nootropic. NA-Selank (N-acetyl selank amidate) is a chemically modified analog sold in the research market; it is not the drug registered in Russia and has its own, thinner evidence base.

### Is Selank FDA-approved?

FDA lists selank acetate (TP-7) among compounding nominations withdrawn by their nominators after being placed in its safety-risk category, noting possible immunogenicity and that the agency lacks important information on its safety in humans.

### What is Selank researched for?

The sources cited on this page most often discuss three outcomes: Less anxiety, small open studies; Less fatigue, small studies; Immune modulation, small study. Each line above shows what the source reports and how strong that evidence is.

### What side effects of Selank are reported?

Reported in the cited sources: Nasal irritation, sleep changes, occasional nausea/elevated heart rate, brief dulling; No long-term Western safety data; FDA flags a possible immunogenicity risk from aggregation and peptide-related impurities in compounded selank acetate, and says it lacks human safety information. The list is not complete, and few listed risks does not mean a compound is safe.

### How strong is the evidence for Selank?

Evidence label: Early human. Small Russian human studies (not placebo-controlled) + animal data + anecdotes; approved in Russia only.

### What else is Selank called?

Names used for it include TP-7, Selank acetate, Selanc, TKPRPGP, Thr-Lys-Pro-Arg-Pro-Gly-Pro, NA-Selank, N-Acetyl Selank Amidate, selank nasal spray, chill peptide.

### Does humanpeptides.fyi recommend Selank?

No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.

---
Family: [Mind & Mood](https://humanpeptides.fyi/peptides?cat=mind). HTML version: <https://humanpeptides.fyi/peptides/selank>. Disclaimer: <https://humanpeptides.fyi/disclaimer>