Calm & Mood

Anxiety, stress and emotional steadiness.

6 peptides · 18 linked sources

Calm & Mood: 6 peptides and related compounds in this index have at least one researched benefit that sources link to calm & mood. Those with approved or trial-backed evidence: Cagrilintide.

Peptides discussed for calm & mood, at a glance
PeptideEvidence labelWhat sources discuss for this goal
SelankEarly humanLess anxiety, small open studies
Semax + SelankUnstudiedFocus and calm, anecdotal; See Selank
DSIPEarly humanWithdrawal relief, old uncontrolled study; Stress-axis calming, early data
KisspeptinEarly humanDesire and arousal
CagrilintideTrial-backedQuieter food noise
NAD+Early humanEnergy and focus, anecdotal

Listed when one of a peptide's three researched benefits relates to calm & mood. Strongest evidence first. Inclusion is not a recommendation, and some listed effects are unproven or failed in trials.

Trial-backed

Larger randomized human trials exist, positive or negative, but no US approval for the uses discussed.

  1. Cagrilintide

    Weight loss, Bigger results with semaglutide, Quieter food noise

    03 Quieter food noise

    • Reduced 'food noise' and appetite (CagriSema EASD 2026 data; Reddit users describe strong appetite suppression at varying doses)human trial + anecdotal1516
    Side effects, quotes and full profile

Early human

Small, short, old, unblinded or single-group human studies.

  1. Selank

    Less anxiety, small open studies, Less fatigue, small studies, Immune modulation, small study

    01 Less anxiety, small open studies

    • Reduces anxiety in generalized anxiety disorder/neurasthenia comparably to benzodiazepine medazepamsmall Russian human comparative study, not placebo-controlled123
    Side effects, quotes and full profile
  2. DSIP

    Sleep, small mixed trials, Withdrawal relief, old uncontrolled study, Stress-axis calming, early data

    02 Withdrawal relief, old uncontrolled study

    • Withdrawal symptoms: in 107 alcohol/opiate withdrawal patients, rapid symptom improvement reported in 97% of opiate and 87% of alcohol casesold uncontrolled human study78

    03 Stress-axis calming, early data

    • Stress-axis modulation: reduced CRF-induced corticosterone in rats and lowered basal ACTH in normal men, though no effect on CRH- or meal-induced ACTH/cortisol in humansanimal + small human studies91011
    Side effects, quotes and full profile
  3. Kisspeptin

    LH and testosterone rise, Desire and arousal, Safer IVF trigger

    02 Desire and arousal

    • Enhances sexual desire/arousal brain processing; in men with HSDD, kisspeptin-54 increased sexual brain activity, penile tumescence and desirehuman fMRI RCTs121314
    Side effects, quotes and full profile
  4. NAD+

    Raises NAD+ levels, Mitochondria and sirtuins, lab data, Energy and focus, anecdotal

    03 Energy and focus, anecdotal

    • Users report energy, focus and mood boosts after injections, highly variable/possibly placeboanecdotal Reddit1718
    Side effects, quotes and full profile

Unstudied

No direct studies of this product or blend. Anecdote and component data only.

  1. Semax + Selank

    Focus and calm, anecdotal, See Semax, See Selank

    01 Focus and calm, anecdotal

    • Combined intent: Semax focus/cognition plus Selank anxiety reduction; users report clearer focus, less anxiety and better work output, others only subtle effectsanecdotal Reddit/forum45

    03 See Selank

    • See Selank: anxiolytic comparable to medazepam in GAD (small Russian human study) and immunomodulation16
    Side effects, quotes and full profile

Questions about calm & mood

Which peptides are discussed for calm & mood?

Selank, Semax + Selank, DSIP, Kisspeptin, Cagrilintide, NAD+.

Which have the strongest evidence for calm & mood?

Labelled approved or trial-backed: Cagrilintide. Approval covers specific uses only.

Is any of this a recommendation?

No. humanpeptides.fyi makes no claims of its own. Each entry reports what cited sources say, with links. Talk to a licensed clinician.

Before you go in

humanpeptides.fyi is an educational index for adults. It summarizes and links to what others have published and reported about peptides and related compounds studied or used in humans. It is not medical advice and gives no dosing guidance. Many listed compounds are not approved for human use, and listing one is not a recommendation. Anecdotes are unverified. Images are AI-generated. By continuing, you agree to the Disclaimer and Terms of Use and the Privacy Notice.

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