Libido & Sexual Health

Desire, arousal and erectile function.

5 peptides · 18 linked sources

Libido & Sexual Health: 5 peptides and related compounds in this index have at least one researched benefit that sources link to libido & sexual health. Those with approved or trial-backed evidence: PT-141, HCG.

Peptides discussed for libido & sexual health, at a glance
PeptideEvidence labelWhat sources discuss for this goal
PT-141Approved (specific use)Desire in women, FDA-approved; Erectile function in men; Arousal boost, anecdotal
VIPEarly humanErectile function, approved abroad
Melanotan IIEarly humanErections in psychogenic ED
KisspeptinEarly humanDesire and arousal
HCGApproved (specific use)Size, libido and mood, anecdotal

Listed when one of a peptide's three researched benefits relates to libido & sexual health. Strongest evidence first. Inclusion is not a recommendation, and some listed effects are unproven or failed in trials.

Approved (specific use)

Approved by the FDA (or a major regulator) for at least one specific use. Approval covers that use only, not the other benefits listed.

  1. PT-141

    Desire in women, FDA-approved, Erectile function in men, Arousal boost, anecdotal

    01 Desire in women, FDA-approved

    • Increases sexual desire and reduces related distress in premenopausal women with HSDDtwo 24-week phase 3 RECONNECT RCTs12

    02 Erectile function in men

    • Improves erectile function in men with ED, including some sildenafil non-respondersphase 2 human RCTs; not approved for men345

    03 Arousal boost, anecdotal

    • Men report spontaneous erections and libido/arousal boost starting hours after dosing and lasting into the next day; others get erections without increased desireanecdotal Reddit678
    Side effects, quotes and full profile
  2. HCG

    Keeps testicular function on TRT, Treats male hypogonadism, Size, libido and mood, anecdotal

    03 Size, libido and mood, anecdotal

    • TRT users report restored testicular size, better libido, sensitivity and semen volumeanecdotal/Reddit161718
    Side effects, quotes and full profile

Early human

Small, short, old, unblinded or single-group human studies.

  1. VIP

    Immune balance, small studies, Erectile function, approved abroad, Mold-related illness, small studies

    02 Erectile function, approved abroad

    • Erectile dysfunction: aviptadil/phentolamine intracavernosal injection (Invicorp) approved in UK for men failing oral therapy; 187-man crossover vs alprostadil showed less pain/fewer adverse eventshuman trial, approved drug910
    Side effects, quotes and full profile
  2. Melanotan II

    Tanning without UV, small trials, Erections in psychogenic ED, Appetite suppression, animal

    02 Erections in psychogenic ED

    • Initiates erections in men with psychogenic ED (8/10 men; double-blind crossover) and organic EDsmall human RCTs1112
    Side effects, quotes and full profile
  3. Kisspeptin

    LH and testosterone rise, Desire and arousal, Safer IVF trigger

    02 Desire and arousal

    • Enhances sexual desire/arousal brain processing; in men with HSDD, kisspeptin-54 increased sexual brain activity, penile tumescence and desirehuman fMRI RCTs131415
    Side effects, quotes and full profile

Questions about libido & sexual health

Which peptides are discussed for libido & sexual health?

PT-141, VIP, Melanotan II, Kisspeptin, HCG.

Which have the strongest evidence for libido & sexual health?

Labelled approved or trial-backed: PT-141, HCG. Approval covers specific uses only.

Is any of this a recommendation?

No. humanpeptides.fyi makes no claims of its own. Each entry reports what cited sources say, with links. Talk to a licensed clinician.

Before you go in

humanpeptides.fyi is an educational index for adults. It summarizes and links to what others have published and reported about peptides and related compounds studied or used in humans. It is not medical advice and gives no dosing guidance. Many listed compounds are not approved for human use, and listing one is not a recommendation. Anecdotes are unverified. Images are AI-generated. By continuing, you agree to the Disclaimer and Terms of Use and the Privacy Notice.

Leave

Your answer is saved only in this browser.